Minnesota Administrative Rules

4717.7840 FOR CANCER.

Subpart 1.

Scope.

This part establishes the methods for determining a health risk limit for cancer.

Subp. 2.

Equation for cancer for chemicals other than chemicals for which a lifetime adjustment factor has been derived or nonlinear carcinogens.

The equation for deriving the health risk limit for cancer for chemicals other than chemicals identified in subpart 3, or nonlinear carcinogens is:

	(1x10-5) x 1,000
cHRL=	_
	[(SFxADAF<2xIR<2xD<2)+(SFxADAF2 to <16xIR2 to <16xD2 to <16)+(SFxADAF16+xIR16+xD16+)]/70 years

Where:

A.

cHRL is the cancer health risk limit expressed as µg/L.

B.

(1x10^-5) is the additional cancer risk level.

C.

Units 1,000 are as described in part 4717.7830, subpart 2.

D.

SF or slope factor is expressed in units of cancer incidence per mg/kg-day. The SFs utilized for each chemical are listed in part 4717.7860.

E.

ADAF is the age-dependent adjustment factor as defined in part 4717.7820, subpart 3. The ADAFs utilized for each chemical are listed in part 4717.7860.

F.

IR_duration is the intake rate for a given duration as defined in part 4717.7820, subpart 14. The IRs utilized for each chemical are listed in part 4717.7860.

G.

D is the duration corresponding to the three age groups birth up to two years of age (two-year duration), two up to 16 years of age (14-year duration), and 16 up to 70 years of age (54-year duration) as defined in part 4717.7820, subpart 9, item B.

H.

70 years is the standard lifetime duration utilized by the United States Environmental Protection Agency in the characterization of lifetime cancer risk.

Subp. 3.

Equation for cancer for chemicals for which a lifetime adjustment factor has been derived.

The Department of Health may depart from the default equation presented in subpart 2 when an adjustment factor is based on chemical-specific information. The equation for deriving the health risk limit for cancer for these chemicals is:

	(1x10-5) x 1,000
cHRL=	_
	[SFxAFlifetime x IRlifetime]

Where:

A.

Units or values for cHRL, (1x10^-5), 1,000, and SF are as described in part 4717.7840, subpart 2.

B.

AF_lifetime is the lifetime adjustment factor utilized to adjust the adult exposure-based SF for lifetime exposure based on chemical-specific data. The AF_lifetime utilized is described in part 4717.7860.

C.

IR_lifetime is the 95th percentile water intake rate representative of a lifetime period.

Statutory Authority:

MS s 103H.201

History:

33 SR 1792

Published Electronically:

May 11, 2009